Each year, around one million women in the Netherlands undergo mammograms for early detection of possible breast cancer. It's an unpleasant procedure involving X-rays which can be a contributor to the onset of cancer.

Researchers at Eindhoven University of Technology, however,  are working on a ‘breast-friendly' method, without radiation, that is more accurate and generates 3D rather than 2D images. They published their proof of concept last month in the online journal Scientific Reports.

In the regular screening method the breast is squeezed tight between two plates in order to produce one or more good X-ray photos. Apart from being unpleasant, it is not without risk because of the harmful rays. Moreover, it is often unclear whether the anomaly found is a cancer or not. More than two-thirds of the cases where something worrying can be seen on the X-ray photos is false-positive: after the analysis of biopsies they are not found to be cancers. This is why science is seeking alternatives.

Researchers at TU Eindhoven have now cleared a major scientific hurdle towards a new technology in which the patient lies on a table and the breast hangs freely in a bowl. Using special echography (inaudible sound waves) a 3D image of the breast is made where cancer can be identified; the researchers therefore expect there to be many fewer false-positive results.

The new technology builds on the patient-friendly prostate cancer detection method developed at TU/e whereby the doctor injects the patient with harmless microbubbles. An echoscanner allows these bubbles to be precisely monitored as they flow through the blood vessels of the prostate. Since tumors and healthy tissue have different blood vessel structures, the presence and location of tumors become visible. This method works well for the prostate and this is now being widely tested in hospitals in the Netherlands, China and, soon, Germany. For breast cancer the method had not yet been suitable due to motion and because the breast is too large, which seriously limits the possibilities of a standard echoscanner.

Researchers Libertario Demi, Ruud van Sloun and Massimo Mischi have now developed a variant of the echography method that is suitable for breast investigation. The method is known as Dynamic Contrast Specific Ultrasound Tomography. Echography with microbubbles uses the fact that the bubbles will vibrate in the blood at the same frequency as the sound produced by the echoscanner, as well as at twice that frequency; the so-called second harmonic. By capturing the vibration, you know where the bubbles are located. But body tissue also generates harmonics, and that disturbs the observation.

For the new method the researchers are using a phenomenon that Mischi happened upon by chance and later investigated its properties together with Demi. They saw that the second harmonic was a little delayed by the gas bubbles. The researchers have now developed a new visualization method. The more bubbles the sound-wave encounters on its route, the bigger the delay. By measuring the delay, the researchers can thus localize the gas bubbles and do so without any disturbance because the harmonic generated by the body tissue is not delayed, and is therefore discernible. This difference, however, can only be seen if the sound is captured on the other side. So this method is perfectly suited to organs that can be approached from two sides, like the breast.

The researchers are currently putting together an international, strong medical team to start performing preclinical studies. Application in practice is certainly ten or so years away, Mischi expects. Moreover, he forecasts that the technology that has been developed will probably not operate on a standalone basis but in combination with other methods, which will create a better visualization. One of the candidates for this elastography, a variant of echography whereby the difference in the rigidity of the tumor and healthy tissue can be used to detect cancer.

(Source: Eindhoven University of Technology)

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